Kirkville is a city in Wapello County, Iowa, United States. The population was 157 at the time of the 2020 census. Kirkville was laid out in 184…Kirkville is a city in Wapello County, Iowa, United States. The population was 157 at the time of the 2020 census. Kirkville was laid out in 1848 by John Kirkpatrick. According to the United States Census Bureau, the city has a total area of 0.56 square miles, all land.