Mecklenburg County is a county located in the southwestern region of the U.S. state of North Carolina, in the United States. As of the 2020 census, the population was 1,115,482, making it the second-most populous county in North Carolina, and the first county in the Carolinas to surpass one million in population. Its county seat is Charlotte, the state's largest m…Mecklenburg County is a county located in the southwestern region of the U.S. state of North Carolina, in the United States. As of the 2020 census, the population was 1,115,482, making it the second-most populous county in North Carolina, and the first county in the Carolinas to surpass one million in population. Its county seat is Charlotte, the state's largest municipality.