For decades, the diagnosis of multiple myeloma required evidence of end-organ ... locus on chromosome 14q32. A small proportion of patients (less than 5%) have both cytogenetic abnormalities.

Plasma cell leukemia (PCL) is a rare disease that may present de novoor secondary to plasma cell myeloma. Advanced disease ... are frequently associated with 14q32 translocations, the most common ...

So what you want to determine is, how serious is the multiple myeloma? How extensive is it? How is it affecting other organs? There's a big spectrum with multiple myeloma and all these plasma cell ...