If tumor suppressor genes get turned off due to mutations, cells are at risk of becoming cancerous and growing uncontrollably. Most cancer cells have more than 60 mutations. A challenge for ...

Medulloblastoma is a malignant, invasive embryonal tumor that predominantly arises in the cerebellum. It is the most common brain tumor in children and constitutes 10–20% of pediatric central ...

They add that because this gene, known as PTPRD, has recently been found to be inactivated in several other cancers as well, their discovery suggests that PTPRD may play a tumor suppressor role in ...

Scientists have developed a method which is able to switch ‘tumor suppressor’ genes back on after they have been silenced by cancer cells. The discovery has strong implications for the ...

Moreover, FGL1 was more profoundly repressed than another tumor-suppressor gene DLC1 located on the same 8p22 region. This was also found for MT1G and SERPINF2, which displayed more repressed ...

Scientists have found a tumor suppressor gene, RASA2, that drives a particularly deadly form of melanoma as well as regulates a key protein, RAS, that is a major oncogene. The discovery is "highly ...

The research confirms previous knowledge that a decreased copy number correlates with mutations in tumor suppressor genes (which hinders their cancer-protective functions), while an increased copy ...

When it comes to genes associated with cancer, none have been studied more extensively than p53, a tumor suppressor gene that serves as the guardian of our genetic information.

These findings provide evidence that promoter methylation of Dkk-3 is a common event in gastric cancer and that Dkk-3 is a tumor suppressor gene through the inhibition of Wnt signaling.

The role of p53 as an anti-cancer, or tumor suppressor, gene has been well-established. It works by blocking cell growth, or inducing cellular suicide, when cells are under stress or dividing ...

This genetic abnormality is associated with a worse outcome. Scientists have identified a gene on that portion of chromosome 6 that functions as a tumor suppressor. Cancers missing this gene may be ...

The headcase gene is homologous to the human HECA gene, and it plays a key role in cancer, acting as a tumor suppressor in both organisms, as it slows down cell cycle. Besides identifying headcase ...