Large families of membrane-binding proteins were recently found to interact with WASP and WAVE family proteins, therefore providing a new layer of membrane-dependent regulation of actin ...

Actin is one of the most abundant proteins in eukaryotic cells. It exists primarily as monomers (G-actin) bound by G-actin binding proteins that prevent spontaneous nucleation of new actin filaments, ...

and actin binding proteins that play a role in both exocytosis and endocytosis. Upon activation, the actin network depolymerizes to allow for fusion of secretory vesicles with the plasma membrane for ...

DHHC5 mediates the palmitoylation of CRYBG1, an actin-binding protein, thereby regulating the localization of VEGFR2 in lipid rafts of lymphatic endothelial cells (LECs). This process is crucial f ...

Their work, published in Nature Communications, reveals a mechanism of interdependence of different forms of the cytoskeletal proteins actin and myosin, and their functions. The team also ...

Discovery of new F-actin-binding proteins for cell-cell and cell-matrix junctions: Two new F-actin-binding proteins (neurabin and nexilin) were found. Neurabin controls the actin cytoskeleton ...