A cartoon showing the asymmetry in the weak binding between myosin and actin that biases the direction of their dissociation. Credit: Osaka University Researchers love to use cartoons to demonstrate ...

(A) The basic organization of a sarcomere subregion, showing the centralized location of myosin (A band). Actin and the z discs are shown in red. (B) A conceptual diagram representing the ...

The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction.

Cells use the polymerization of actin alone to create some types of movement, but many other forms of movement require interplay between actin and an enzyme called myosin. Credit: extender_01 ...

Their work, published in Nature Communications, reveals a mechanism of interdependence of different forms of the cytoskeletal proteins actin and myosin, and their functions. The team also ...

The researchers designed an optogenetic tool to directly inactivate nonmuscle myosin II, which generates cellular contractility in coordination with actin filaments. To achieve this, they focused ...

Other experiments demonstrated that LTP induction activates myosin through the N-methyl-D-aspartic acid (NMDA) receptor and downstream Rho-GTPase signaling. To see what was happening to actin at the ...

In addition, more than 90 percent of the total volume of a skeletal muscle cell is composed of muscle proteins, including the contractile proteins actin and myosin. When a muscle cell is activated ...