The proto-oncogene (top) is depicted as a regulatory sequence (RS) followed by the coding region (gene). In the first example, a star indicates the location of the nucleotide substitution on the ...

When oncogenes (genes known to drive cancer) were activated in these mice, tumors arose about 40% of the time, compared with ...

Two newly identified disease-causing genes, known as Bzw2 and Eif5a2, have been implicated in early prostate cancer ...

Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue ... refined model of KRAS activation informed by ...

Another type of cell stress that can induce p53 activity is oncogenic activation. Oncogenes, such as myc, ras or beta-catenin, are cell regulatory proteins whose function becomes disrupted through ...

Funded by Prostate Cancer UK, the ICR team focused on genes involved in the PI3K-AKT pathway, which is frequently mutated in ...