Dopamine’s effects in the brain are mediated by postsynaptic D1 and D2 receptors. Adenosine A1 and A2A receptors are uniquely positioned to counteract the excessive stimulation of dopamine receptors ...

Marvel Biosciences Corp. (TSXV: MRVL) and its wholly owned subsidiary, Marvel Biotechnology Inc. (collectively the "Company" ...

Oxford, UK-based Exscientia has been working with German biotech Evotec on the adenosine A2a receptor antagonist, which is being tested as a treatment for adult patients with advanced solid tumours.

KW-6356 has a higher affinity and selectivity for adenosine A2A receptors, leading Kyowa Kiri to speculate that it could obtain approval for a wider group of Parkinson's patients than Nourianz.

The mechanism of action of these different terpenes is through the adenosine A2a receptor – a receptor that caffeine targets and blocks. Each of the terpenes resulted in high levels of pain ...

He has found that HIF-2a promotes endothelial proliferation independent of HIF-1a. He has also found that adenosine A2A receptor is a unique downstream target gene of HIF-2a that can also promote ...

Like traditional animal-derived PDRNs, BluePDRN™ demonstrated skin regeneration efficacy through an adenosine A2A receptor (A2AR)-dependent mechanism. Notably, the regenerative benefits of ...

a dual A2a/A2b adenosine receptor antagonist, which is in phase 2 clinical trial for colorectal cancer; and Zimberelimab, an anti-PD-1 antibody. In addition, the company develops AB598 ...