A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose tissue fibrosis, a condition closely linked to ...

Endotrophin serves as a powerful co-stimulator of pathologically relevant pathways within the ‘unhealthy’ adipose tissue milieu, triggering fibrosis and inflammation and ultimately leading to ...

Ultimately, the findings underscore the potential of miRNA-based therapies as a non-invasive, targeted strategy to combat fibrosis in both adipose tissue and other organs. Genes & Diseases ...

Cirius Therapeutics, Inc., developing innovative therapies for patients suffering from diseases caused by insulin resistance, ...

LISBON, PORTUGAL — A novel and easy-to-use score that measures fibrosis in human subcutaneous adipose tissue (scAT) could help to identify patients who are poor responders to Roux-en-Y gastric ...

The researchers also found that senescent macrophages secrete a variety of factors, one of which is a molecule called osteopontin which they found is responsible for adipose tissue fibrosis.

Adipose tissue is an underappreciated and misunderstood organ. Capable of more than doubling in mass and then returning to baseline, 1 white adipose tissue (WAT) continues to play an essential ...

presented data from a study that aimed to identify matrisome regulator miRNAs in obesity and prediabetes that could represent novel noninvasive circulating biomarkers of adipose tissue (AT) fibrosis.

34.1%) and improvement in fibrosis (37% vs ... diabetes-associated hyperinsulinemia and hyperglycemia) and adipose tissue dysfunction (characterized by lipodystrophy, visceral adiposity, insulin ...

The review also draws attention to miRNAs' systemic impact, noting how alterations in adipose tissue can influence fibrosis in distant organs, including the liver, heart, and kidneys. For example ...