DESIGN: The effect of a systemic nicotine infusion (0.5 µg/kg/min for 30 min) on lipolysis in subcutaneous adipose tissue was investigated in situ in 11 non-obese, non-smoking, healthy male ...

Presentation to highlight WVE-007 (INHBE GalNAc-siRNA) as a potential novel and unique obesity treatment leading to healthy weight loss and supporting preclinical data demonstrating potent and durable ...

In adipose tissue from study participants with the DD genotype, the mutation resulted in the absence of HSL protein, small adipocytes, impaired lipolysis, insulin resistance, and inflammation.

Specifically, they examined how the effect of colonic fermentation on enteroendocrine secretion, insulin clearance, and lipolysis of adipose tissue could be associated with insulin resistance and ...

Reference: Townsend LK, Wang D, Knuth CM, et al. GDF15 links adipose tissue lipolysis with anxiety. Nat Metab. 2025. doi: 10.1038/s42255-025-01264-3 This article has been republished from the ...

Now, we found that the weight loss is largely due to the loss of adipose tissue by lipolysis, a metabolic process that breaks triacylglycerols into their constituent molecules, including free ...

“Genetic deletion of Akr1b3 or pharmacological blockade of AKRIB3 with zopolrestat reduced HFD-induced obesity, attenuated markers of adipose tissue senescence, and increased lipolysis.

Understanding the link between adipose tissue and anxiety opens up new avenues ... initiates a process called lipolysis in fat cells. This process leads to the release of fats, which in turn ...

A new study reveals a novel connection between aging of visceral adipose tissue and brain health. These findings are ...

More information: Logan K. Townsend et al, GDF15 links adipose tissue lipolysis with anxiety, Nature Metabolism (2025). DOI: 10.1038/s42255-025-01264-3 Provided by McMaster University ...