Aims: To determine the maximum tolerated dose (MTD), safety and anti-tumor activity of afatinib combined with docetaxel in advanced cancer. Patients & methods: The MTD was determined from dose ...
Afatinib is a novel, potent, oral irreversible ErbB family blocker that has reached Phase III clinical development. It covalently binds and irreversibly blocks signalling from all the cancer ...
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