Akt2-/- mice are also resistant to thrombosis in an arterial injury model. In contrast, the Akt substrate, Glycogen synthase kinase (GSK)3beta, is a negative regulator of platelet signaling and ...

Detects pSer/Thr preceded by Lys/Arg at positions -5 and -3. Some cross-reactivity with pSer/Thr preceded by Arg/Lys at positions-3.

PKB/AKT, protein kinase B; S6K, ribosomal protein S6 kinase.) However, the discovery of the way in which 'primed' substrates dock with GSK3 might have opened up a new opportunity to develop ...