"Selective click reactions with molecules that have both azide and alkyne moieties are not easy, but we were able to elucidate that each click reaction proceeds in a highly selective manner by ...

The Cu(I)-catalyzed cycloaddition reaction between an alkyne group and an azide group, better known as 'click chemistry,' has proven its utility in a multitude of applications in biology.

Figure 1: Illustrations of the ways that proximity-mediated 'click' chemistry has been used ... added a terminal alkyne and repeated the process. The result was a trivalent ligand with a K D ...