Similarly, alternative splicing of RNA leads to a variety of possible mRNA isoforms and proteins, which can have different, and often opposing, functions (Figure 1).

Alternative splicing enables a single gene to encode multiple mRNA variants and, consequently, diversifies protein isoform products. The advent of deep sequencing technologies has revealed that 95 ...

Patterns of alternative splicing of mRNA differ between tumors and the normal tissues from which they are derived. 2 It has been recognized for some time that aberrant splicing may produce ...

Here is a breakdown of the most common types of alternative splicing. Exon skipping: This process involves the removal of certain exons and their adjacent introns from mRNA constructs prior to ...

Alternative splicing, ... The first therapeutic approval for SMA targets the SMN2 pre-mRNA and binds to a region that is accessed by the splicing machinery to remove exon 7.

Discover how unique circular RNA molecules are transforming liver cancer research to combat this growing health concern.

Alternative splicing (AS) is a genetic process that increases the diversity of proteins that can be generated from genes, ... It already seems wasteful to degrade 15% of mRNA transcripts, ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA).

What role does alternative splicing play in neurodegenerative disease? Date: June 20, 2023 Source: University of California - Riverside Summary: Scientists have written a review to discuss ...

Alternative splicing, ... (RNA before it is spliced), only a small fraction of the pre-messenger RNA makes into the final messenger RNA, or mRNA, transcript that encodes protein.

RIVERSIDE, Calif. -- Alternative splicing, a clever way a cell generates many different variations of messenger RNAs — single-stranded RNAs involved in protein synthesis — and proteins from ...