Aminoacyl tRNA synthetases picked up new protein domains that participate in vasculature formation around the same time that organisms evolved key adaptations in the circulatory system. Amber Dance is ...

HARS WHEP is part of an ancient class of proteins known as aminoacyl-tRNA synthetases (aaRSs). Typically, aaRSs play a key role in protein synthesis. "They're in every cell in your body.

further selections and tinkering will probably yield substantial improvements — molecules that come closer to having the catalytic activity of modern protein-based aminoacyl-tRNA synthetases.

McC analogs with an altered terminal amino acid retain the Trojan-horse mechanism of action but target aminoacyl-tRNA synthetases specified by an amino acid coupled to AMP. Clustered homologs of E.