These signaling events and Notch family members are discussed in greater detail in other reviews presented in this issue. However, the pertinence to angiogenesis and the mechanisms by which Notch ...

Angiogenesis, the formation of new blood vessels from preexisting vasculature, is essential for many physiological processes, such as wound healing, and also plays a critical role in many ...

Several newly developed angiogenesis inhibitors work by blocking vascular endothelial growth factor (VEGF), an important signaling protein that spurs growth of new blood vessels. Avastin ...

The induction of Dll4–notch signaling is thought to act as a damping mechanism to prevent excessive angiogenesis and to promote the orderly development of new blood vessels. Blockade of Dll4 ...

Angiogenesis refers to the generation of new blood vessels in your body that support the growth and repair of tissue. It’s a process that’s controlled by chemical signaling between your cells.

signaling pathway. Using a combination of molecular and cellular studies alongside the use of mouse models they have been able to analyze the pathway’s in vivo function and investigate its involvement ...

Among other areas, researchers are examining markers of angiogenesis and the specific signaling pathways through which angiogenic proteins are controlled. They are developing methods, including ...

Although comprehensive epigenetic datasets, especially in cancer cells or stem (ES/iPS) cells, have been constructed, the changes in epigenome dynamics in normal vascular endothelial cells upon ...

This steady equilibrium is maintained through the activity of cellular signaling pathways, particularly through the activation of growth factor receptors. Angiogenesis is split into two main types: ...

The Ras/Raf signaling pathway is an important mediator of tumor cell proliferation and angiogenesis. Mouse embryos lacking B-raf or Raf-1 fail to develop due to vascular effects and increased ...

Angiogenesis involves the generation of new ... in the differentiation and shaping the new vascular branch is Notch signaling. VEGF stimulates the secretion of Delta-like 4 (DLL4) in the tip ...

They found that when vascular endothelial cells receive VEGF signaling, a unique "bivalent histone switch" that is limited to immediate-early type transcription factors essential for angiogenesis ...