Considerations regarding the modes and underlying mechanisms of resistance to antiangiogenic therapy ... concurrent use of antiproliferative agents. Another unanswered question is whether cancer ...

Both TACE and TAE result in hypoxia, which stimulates angiogenesis, promoting tumor growth; thus combination of TACE with antiangiogenic agents may improve current results. To date, there is no ...

Various preclinical experiments in his laboratory supported this hypothesis, and subsequent clinical trials led by Jain and his clinical collaborators confirmed that antiangiogenic agents improve ...