Glioma angiogenesis is mediated by angiogenic factors that induce an abnormal, inefficient vascular network. Several proangiogenic molecules have been identified in brain tumors ( Table 1). The ...

Glioblastoma multiforme is an extreme example. Antiangiogenic therapy has been combined with radiotherapy with mixed results: additive or synergistic tumor growth delay, or reduced response.

Ovarian Cancer Targeted Medication: PARP Inhibitors, Anti-Angiogenic Drugs, Immunotherapy, and More Ovarian cancer is the malignancy with the highest rate of death from tumors of the female ...

Treatment options for patients with glioblastoma multiforme (GBM), the most common form of malignant gliomas, now include anti-angiogenic therapy after failure of standard multi-modality treatments.

Angiopoietin-2 (ANGPT2) is a ligand of the receptor tyrosine kinase TIE2 (TEK). In conjunction with vascular endothelial growth factor (VEGF), ANGPT2-TIE2 signaling induces vascular sprouting.

Angiopoietin-2 (ANGPT2) is a ligand of the receptor tyrosine kinase TIE2 (TEK). In conjunction with vascular endothelial growth factor (VEGF), ANGPT2-TIE2 signaling induces vascular sprouting.