Yeasts have a single Aurora kinase, whereas mammals have three: Aurora A, B and C. During mitosis, Aurora kinases regulate the structure and function of the cytoskeleton and chromosomes and the ...

AURKA inhibitors might enhance outcomes of metastatic prostate cancer treated with androgen receptor pathway inhibitors by intensifying androgen receptor inhibition, increasing DNA-damage-related cell ...

Aurora A overexpression correlates with poor prognosis and is considered a therapeutic target for cancer treatments, although the clinical development of Aurora kinase inhibitors has been so far ...

VIC-1911 is an oral selective Aurora kinase A inhibitor (AURKA). The trial is being carried out at the University of Minnesota Medical School, Hematology and Transplantation, with Shernan G.

A phase I study of SRA737 (formerly known as CCT245737) administered orally in patients with advanced cancer. Background: Aurora kinase B performs key roles in the regulation of the cell cycle and ...

Lung metastasis targeting by a tumor-killing Salmonella typhimurium mutant. Background: Aurora B kinase is involved in coordinating multiple steps of mitosis, including chromosome condensation, ...