Xanthine oxidase inhibitors such as allopurinol or febuxostat increase the production of myelotoxic metabolites from azathioprine. Initiation of azathioprine should be accompanied by regular ...

Measurement of red blood cell levels of azathioprine metabolites, such as 6-thioguanine nucleotides, can be used to confirm TPMT phenotype and to monitor compliance with the medication ...

Azathioprine is an immunosuppressant, prescribed for prevention of rejection kidney transplantation. The serum concentration of the active metabolites of Azathioprine can be increased when ...

This study aimed to critically appraise the current level of economic evidence available for thiopurine S-methyltransferase (TPMT) testing of thiopurine drugs, such as azathioprine. Six economic ...

During four courses of such treatment over a 4-year period, her vaginal secretions were yellow, which raised the possibility of secretion of azathioprine or its metabolites that could have led to ...

Mycophenolate versus Azathioprine as Maintenance Therapy for Lupus Nephritis. New England Journal of Medicine , 2011; 365:1886-1895 DOI: 10.1056/NEJMoa1014460 Frédéric A. Houssiau.

Azathioprine (Imuran ... departments of Medicine and Pharmacology and the Section of Metabolism, Department of Medicine, Yale University School of Medicine and the Yale–New Haven Hospital ...

The research identified a `strong case for an association' between the drug azathioprine and the mutational signature found in cases of cutaneous squamous cell carcinoma (cSCC), a common form of ...

Both mycophenolate mofetil and azathioprine have been FDA-approved since the mid-1990s for use in kidney transplant patients, to help prevent organ rejection.Neither is FDA-approved as a ...