Other biologically active proteins, such as insulin and immunoglobulin G, are actively transcytosed through BBB endothelial cells. The presence of receptors involved in the transcytosis of ligands ...
The most advanced molecule is ABL301, an α-synuclein (SNCA)-targeting BsAb that penetrates the BBB via a receptor-mediated transcytosis (RMT) receptor and is in development for Parkinson’s ...
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