The two types of bisphosphonates differ in their mechanism of action for killing osteoclast cells. The non-nitrogenous bisphosphonates are taken up by the osteoclasts, which then die. Nitrogenous ...

Long-term treatment with a bisphosphonate degrades fracture-resistance–toughening mechanisms that contribute to healthy bone, setting the stage for the rare but catastrophic risk of patients ...

"Together, these results suggest a loss of intrinsic and extrinsic toughening mechanisms, which contribute to atypical femoral fractures in patients treated with long-term bisphosphonates," the ...

A discussion of the clinical problem and the mechanism of benefit of this form ... To prevent additional vertebral fractures, oral bisphosphonate therapy was recommended. Bone mineral density ...

The two types of bisphosphonates differ in their mechanism of action for killing osteoclast cells. Bisphosphonates are usually taken as tablets but can also be given by injection. These drugs can ...

24 Figure 1: Mechanism of bisphosphonate accumulation in the jaw and a hypothetical pathogenic role in osteonecrosis. To explain osteoradionecrosis, the hypothesis of hypovascularity and hypoxia ...

Atypical femoral fractures have been associated with long-term bisphosphonate treatment. 1,2 However, the underlying mechanisms remain obscure. We studied three sisters who had atypical femoral ...

"Although possible mechanisms need further exploration, there is an urgent need to examine this interaction in studies of other bisphosphonates in osteoporosis and other bone diseases," McCloskey ...

Although the mechanism of action of the bisphosphonates has yet to be fully elucidated, the characteristic P-C-P bond enables them to bind to mineralised bone matrix, thereby inhibiting osteoclast ...

11 This goal requires a better understanding of the mechanisms of action and the overall balance of risks and benefits of pharmacologic interventions such as the bisphosphonates, which are ...

Bisphosphonates have proven effective as ... so I don’t think one can really speak to mechanisms at this point,” said Laurie K. McCauley, DDS, PhD, professor and chair of the department ...