Table 2. Associations of brown fat, obesity and loss/mutation of tumor suppressor genes in endometrial and breast cancer. † P53 mutation in case of PTEN or BRCA1 mutation. ‡ Brown fat state in ...

Further analysis of the cellular composition showed that the heterogeneity of ICs, MCs, and FAPs was particularly pronounced, while the heterogeneity of adipocytes and ECs was relatively small.

In this study, we employed snRNA-seq to test five representative depots including inguinal, epididymal, mesenteric, perirenal, and pericardial adipose tissues in mice under physiological conditions.

Adipose tissue is connective tissue primarily comprised of white and brown adipocytes ... it has a plethora of functional roles within the human ... subcutaneous WAT is heterogeneous in nature.

The scRNA-seq and functional analyses identify distinct progenitor populations contributing to BAT regeneration. ... may act as progenitors of brown adipocytes and participate in BAT regeneration.

Brown adipocytes are specialized cells that can use energy to produce heat. This property makes them attractive tools for the treatment of diseases like obesity and type 2 diabetes. Until recently ...

Our study addresses this challenge by resolving the heterogeneity of human stem cell–derived islet organoids and introducing a functional marker to isolate transplant-ready islets." ...

Evidence of Obesity Heterogeneity & Its Importance With Regard to Cancer Clearly, the abovementioned aspects include the specific features of obesity itself; some of these features are described ...