Cyclooxygenase–2 (COX-2) is upregulated in many tumors ... Here, we show that COX inhibitors inhibit the growth of neuroblastoma and when combined with low doses of chemotherapy, exert ...

"The outcomes we observed with COX-2 inhibitors and IDO1 inhibitors were ... "It is always very useful to have two compounds acting on the same pathway with two different modes of action: In ...

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. However, research on COX-2 regulation of ferroptosis ...

Q. Turmeric and rosemary are two ingredients among ten in an over-the-counter supplement I take. In lab studies, the ...

And it is this increased shunting of arachidonic acid into the 5-LO pathway that may help explain why COX-2 inhibitors contribute to cardiovascular problems, the researchers say. "More studies are ...

New research on the COX-2 pathway indicates that it might be possible for COX ... The results show that COX-2 inhibitors promote heart disease by suppressing production of a fat called prostacyclin, ...

"The COX-2 signaling pathway is important in cancer because when it's activated, it can stimulate many key steps in cancer development, including cell division, inhibition of cell death ...

from the market has intensified controversy about the safety of cyclooxygenase (COX)-2 inhibitors. Results from several recently published studies address this issue. In yet another study ...

as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ferrous ion overload, lipid peroxidation, and excessive oxidative stress. Inhibition of COX-2 ...

"The outcomes we observed with COX-2 inhibitors and IDO1 inhibitors were ... "It is always very useful to have two compounds acting on the same pathway with two different modes of action: In ...