Among these candidate genes, regression analysis revealed that osteopontin (OPN ... also upregulates the expression of the OPN receptor (CD44) resulting in the establishment of an autocrine ...

for which hair stem cells had a matching receptor molecule called CD44. Upon molecular interaction between osteopontin and CD44, hair stem cells became activated, resulting in robust hair growth.

CD44 has a pivotal role in regulating the properties of CSCs, including their self-renewal, tumor initiation, metastasis, and chemoradioresistance, and OPN reportedly interacts with CD44.

Osteopontin is recognized by the CD44 receptor on epithelial hair stem cells, which mediates the effect of osteopontin in the hyperactivation of hair growth in the nevus. When either this hormone ...

for which the senescent hair stem cells had a matching receptor molecule called CD44. When osteopontin and CD44 interacted, the stem cells were activated and produced hair. Mice genetically ...

Upon the researchers finding that the senescent pigment cells produced high levels of osteopontin, they also found that hair stem cells had a matching receptor molecule called CD44. Then ...

The aging pigment cells released high levels of osteopontin, which paired with a receptor present on the stem cells called CD44. Once osteopontin interacted with CD44, the stem cells activated, ...

the laboratory determined that CD44 protected the cells from programmed cell death initiated by the Fas receptor. This protective effect was specific to a subset of T cells, the Th1 cells ...

Unlike GLP-1 receptor agonists, which primarily regulate appetite and glucose metabolism, CD44 inhibition addresses obesity through a distinct mechanism by directly impairing adipogenesis.

We investigated the presence of osteopontin in pleural mesothelioma and determined serum osteopontin levels in three populations: subjects without cancer who were exposed to asbestos, subjects ...