HSV-1 is a common virus. During infection, its DNA incorporates into host chromosomes, where it lies dormant. An estimated two-thirds of adults worldwide carry these latent HSV-1 genes. Previous work ...

When STING is triggered, TANK-binding kinase (TBK1) activates and leads to interferon production. However, Tan and his team ...

The cGAS–STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to ...

These efforts are being extended to CRISPR-transposition systems and to provide an understanding of recognition principles involving evolved viral suppressor proteins that inhibit the CRISPR-Cas ...

A new study has uncovered a surprising link between Alzheimer’s disease and Herpes Simplex Virus-1 (HSV-1). Researchers found ...

Research reveals how herpes simplex virus-1 may contribute to Alzheimer’s disease, offering new insights into the disease’s ...

This protective effect worked through the cGAS-STING-TBK1 immune pathway. The research primarily used postmortem brain tissue and laboratory models, which may not fully reflect the complexity of ...

“This led us to explore a specific immune response pathway in the brain, the cGAS-STING pathway,” he detailed. “We found that molecules of this pathway are present where HSV-1 and modified tau are ...

The possibility that Alzheimer’s disease diagnosis is associated with viruses, bacteria, fungi, and parasites has been ...