When STING is triggered, TANK-binding kinase (TBK1) activates and leads to interferon production. However, Tan and his team ...

These efforts are being extended to CRISPR-transposition systems and to provide an understanding of recognition principles involving evolved viral suppressor proteins that inhibit the CRISPR-Cas ...

A new study has uncovered a surprising link between Alzheimer’s disease and Herpes Simplex Virus-1 (HSV-1). Researchers found ...

“This led us to explore a specific immune response pathway in the brain, the cGAS-STING pathway,” he detailed. “We found that molecules of this pathway are present where HSV-1 and modified ...

This protective effect worked through the cGAS-STING-TBK1 immune pathway. The research primarily used postmortem brain tissue and laboratory models, which may not fully reflect the complexity of ...

The herpes simplex virus type can affect the brain in a number of ways including ... “Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer’s disease,” and led ...

These findings could lead to new treatments targeting infections and the brain’s immune response ... Anti-herpetic tau preserves neurons via the cGAS-STING-TBK1 pathway in Alzheimer’s disease. Cell ...