This cycle is divided into several phases, each of which is characterized by distinct cyclin proteins that act as key regulators for that phase. Before a cell can progress from one phase of the ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz ...

Understanding an enigma For decades, cancer researchers and pharmaceutical companies have eyed cyclin dependent kinase ... that it controls the function of proteins called transcription factors ...

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits.

For organs to develop, grow and regenerate, cells must proliferate. But when that process goes awry, leading to uncontrolled cell growth, cancer can emerge.

Positive azenosertib clinical data demonstrated clinically meaningful results in patients with Cyclin E1+ platinum-resistant ovarian cancer ...

Breast cancer is one of the leading causes of mortality among women worldwide. Tumor necrosis factor α-induced protein 3-interacting protein 1 (TNIP1) is a ubiquitin-binding protein that is widely ...

These block proteins called cyclin-dependent kinases and slow the cancer’s growth. Antibody-drug conjugates (ADCs). This type includes drugs like sacituzumab govitecan-hziy (Trodelvy ...

The presentation also demonstrates Cyclin E1 protein overexpression, regardless of CCNE1 gene amplification, as a sensitive and specific predictive biomarker that can be used to identify patients who ...

For decades, cancer researchers and pharmaceutical companies have eyed cyclin-dependent kinase (CDK7 ... found that it controls the function of proteins called transcription factors, which ...