Tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, has been implicated in the pathogenesis of AD. Objective: To investigate the use of a biologic TNF-alpha inhibitor, etanercept was ...

BALTIMORE--(BUSINESS WIRE)--TNF Pharmaceuticals ... through the modulation of numerous pro-inflammatory cytokines including TNF-alpha (TNF-α), an immune cell signaling protein and inflammatory ...

The traditional understanding of inflammation focused primarily on its acute manifestations, the classic signs of redness, ...

TNF Pharma begins phase 2b clinical trial to evaluate oral TNF-alpha inhibitor drug candidate isomyosamine: Baltimore Thursday, February 27, 2025, 18:00 Hrs [IST] TNF Pharmaceutic ...

6 Isomyosamine is a novel plant alkaloid small molecule shown to regulate the immuno-metabolic system through the modulation of numerous pro-inflammatory cytokines including TNF-alpha (TNF-α), an ...

Cite this: TNF-α-induced Up-regulation of Pro-inflammatory Cytokines Is Reduced by Phosphatidylcholine in Intestinal Epithelial Cells - Medscape - Jul 13, 2009. 1 Department of Gastroenterology ...

Image Credit: Sino Biological Inc. Disturbance in levels of the key pro-inflammatory cytokines, such as IL-6, IL-1β, and TNF-α, and anti-inflammatory cytokines, such as IL-10, IL-4, and TGF-β ...

Here we review evidence for the contribution of cytokines to acute neurodegeneration, focusing primarily on interleukin 1 (IL-1), tumour necrosis factor-α (TNFα) and transforming growth factor ...

Contrary to established dogma, the spleen is not the principal source of the pro-inflammatory cytokine called tumor necrosis factor (TNF), which drives the sort of system-wide inflammation seen in ...

Cytokines and their kin, alternatively called interleukins, growth factors, interferons, necrosis factors, and others, are soluble messengers responsible for communication between nearby cells, ...

today announced the initiation of a fully funded Phase 2b clinical trial evaluating oral TNF-alpha (TNF-α) inhibitor drug candidate isomyosamine as a treatment for chronic inflammation associated ...