Normally, T-cells with markers known as CD8 are cytotoxic, and those with the CD4 marker are not, so the authors first thought that perhaps CD8-positive cells were increased. But that turned out ...

The more cytotoxic T cells in the environs of the tumor ... with higher quantities of T cells that expressed the CD200 marker, which became more common after anti-PD-L1 therapy in the patient ...

In summary, this study revealed mutually exclusive reactivity of the widely used B-cell markers CD79a or L26 in a very small proportion of extranodal cytotoxic PTLs and a case of a nasal NK/T-cell ...

This expeditiously yielded polyclonal CTL lines uniformly expressing markers associated with an enhanced survival ... Infused CTLs persisted with frequencies up to 2.9% of CD8 + T cells for as long as ...

The authors immunostained the brain samples with antibodies specific for phosphorylated tau, α-synuclein, the cytotoxic T cell marker CD8, and the microglial marker HLA-DR, then used stereology ...

A panel of T-cell markers that can detect subsets of tumor ... solid tumors with high infiltration of CD8 + T-cells, 6 since cytotoxic T-cells that infiltrate tumors are the critical mediator ...

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

A significant gap in the field of immunology is the process by which immune cells communicate to elicit an effective immune response. T cells are immune cells with multiple functions. There are also ...

As the trained killers of the immune system, cytotoxic T cells silently save our lives every day—vanquishing viruses before they can run amok, and putting nascent cancer cells out of business before ...

These cases led to an FDA black-box warning as of December 2023 and requests for lifelong monitoring of all recipients of CAR T-cell therapy. An additional case of indolent CD4+ cytotoxic CAR+ T ...