show that inhibition of NAD-dependent protein deacetylase sirtuin-6 (SIRT6) in human chondrocytes is associated with increased DNA damage, telomere dysfunction and premature senescence.

This study used etoposide, to induce DNA damage-related senescence or chronic exposure to IL-1β to entail inflammation-related senescence in human OA chondrocytes. Several hallmarks of cellular ...

Experts say vitamin D, known as the "sunshine vitamin," holds promise in the realm of anti-aging. Research suggests that it ...

Scientists at the San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, have found that gene editing using ...

Cellular senescence is a mechanism of cellular aging that has diverse ... and (2) hyperactivation of the DNA damage response may promote mutations and epimutations. Considering the apparent ...

As populations worldwide continue to age, chronic back pain caused by intervertebral disc degeneration is emerging as a ...

Examples of internal stresses leading to senescence include shortening of the telomeres, DNA damage, mitochondrial dysfunction, nutrient deprivation, oncogenic pathway activation. 4 Some examples of ...

However, there is another fate for cells after DNA damage: senescence—a state where cells survive, but stop dividing. Senescent cells' DNA has not been damaged enough to induce apoptosis but is ...

Cellular circuit controls how DNA damage is repaired, affecting risk of disease as we age. ScienceDaily . Retrieved June 1, 2025 from www.sciencedaily.com / releases / 2025 / 03 / 250313192227.htm ...

Vitamin D supplements may help prevent the loss of telomeres, DNA sequences that shrink with aging, a large study shows. But ...

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

A new research paper titled "Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes" has been published in Aging. Senescent cells (SnCs) have been described to ...