The DNA repair and replication pathways converge on a common final step in which the continuity of the repaired DNA strand is restored by DNA ligase, an enzyme that converts nicks into phosphodiester ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, ...

The breaks are caused by a variety of things, including normal cellular processes like DNA replication ... The enzyme DNA ligase 4 is also needed to make vital proteins on the surface of immune ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

Because DNA replication errors or environmental agents ... and that TRIM52 is rapidly degraded by multiple giant E3 ligases. These findings link TRIM52 to genome integrity control.