The structure of the antifungal drug target homoserine dehydrogenase (HSD) was determined from Saccharomyces cerevisiae in apo and holo forms, and as a ternary complex with bound products ...

2 In this review, we discuss the mechanisms of toxicity ... Panel A shows the metabolic pathways of toxic alcohols. Alcohol dehydrogenase and aldehyde dehydrogenase sequentially oxidize the ...

Neuroinflammation contributes to the loss of dopamine neurons and motor dysfunctions in Parkinson's disease (PD). How cell metabolism regulates neuroinflammation by modulating epigenetic modifications ...

A polymorphism in the gene for alcohol dehydrogenase type 3 (ADH3 ... with a reduced risk of myocardial infarction; however, the mechanism underlying this association is unclear.

Methylmalonate semialdehyde dehydrogenase deficiency (MMSDH deficiency ... Despite its significance, the structural and biochemical mechanisms of ALDH6A1 remain poorly explored.

The pyruvate dehydrogenase complex (PDC) plays a pivotal role in linking glycolysis to the tricarboxylic acid (TCA) cycle, but the mechanisms regulating PDC activity—especially through post ...