Four Senate Republicans joined with Democrats on Wednesday to deliver a rare bipartisan rebuke to President Donald Trump over trade policy.

New Hampshire Democratic Rep. Chris Pappas is the first high-profile candidate to enter the Senate race to succeed Sen. Jeanne Shaheen.

The party’s activist base was jolted by a senator’s marathon speech and electoral victories, but questions linger about broad appeal.

Senate Republicans are looking to change how extending many of Trump’s 2017 tax cuts would be scored when it comes to future federal deficits. The Congressional Budget Office has projected that extending the cuts would increase deficits by nearly $4 trillion over the coming decade.

The U.S. Senate on Wednesday is expected to vote on a measure protesting President Donald Trump's new tariffs on Canadian imports, in a move expected to draw some Republican support in that chamber but fall flat in the House of Representatives.