The kidney is a central organ of the mammalian ... BRN1 commits cells to becoming cells of the Henle's loop and distal tubules. Irx genes, possibly together with BRN1, control the fate of the ...

If its ortholog, ClC-K1, is nonfunctional in mice, renal diabetes insipidus develops. ClCKB is a key determinant of tubular reabsorption of chloride and electrolytes along the distal tubule.

even in advanced chronic kidney disease; cysts derived from proximal tubules, but not those derived from distal tubules, contained increased concentrations of bioactive erythropoietin.

Furosemide's primary action is the inhibition of sodium and chloride reabsorption in the proximal and distal tubules and the loop of Henle. Its high diuretic effect is primarily due to its ...

Transform your drug development pipeline with Newcells’ Renal Proximal Tubule Cells Model eBook. This eBook provides insight into the science behind aProximate ™, an innovative proximal tubule ...

Thus, the two types of kidney - opisthonephric and metanephric ... nephrons within opistonephros differentiate into proximal and distal regions. In reptiles, birds and mammals, the metanephric tubules ...

Renal tubule epithelial cells can be oval ... [9] Casts are formed in the distal tubules and collecting ducts where Tamm–Horsfall proteins precipitate and entrap cells present in urine.