Endothelial sprouting and proliferation are tightly coordinated processes mediating the formation of new blood vessels during physiological and pathological angiogenesis. Endothelial tip cells ...

To determine whether the Dll4/Notch pathway has a role during tumour angiogenesis, we manipulated this pathway in experimental tumour models in mice using a variety of genetic and pharmacologic ...

The induction of Dll4–notch signaling is thought to act as a damping mechanism to prevent excessive angiogenesis and to promote the orderly development of new blood vessels. Blockade of Dll4 ...

Crucial for angiogenesis is the Notch receptor -- among others -- and its Dll4 ligand. Pitulescu combined genetic experiments with pharmacological approaches. "This approach allowed us to ...

31. Phng LK and Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev Cell 2009; 16(2): 196–208. 32. Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour ...

Angiogenesis involves the generation ... VEGF stimulates the secretion of Delta-like 4 (DLL4) in the tip cell, binding to Notch-1 receptors expressed on the stalk cells. This results in down ...

"The biochemistry of sprouting angiogenesis is well understood. VEGF leads endothelial cells to express DLL4, which activates NOTCH signaling. What is lacking is a good system to study drugs that ...

to block DLL4 and sequester locally secreted VEGF. 13 In a phase Ia study in patients with refractory solid tumors, navicixizumab monotherapy modulated both Notch and angiogenesis signaling, and ...

In experiments with mouse models of GVHD, the researchers showed that blocking a particular Notch activator known as DLL4 effectively prevented GVHD when administered within the first days after ...

Demcizumab, the company's first Notch pathway product candidate, is currently in Phase 1b clinical testing. The paper entitled "Anti-DLL4 Has Broad Spectrum Activity in Pancreatic Cancer Dependent ...

My research program broadly aims to identify mechanisms through which Notch signaling in vascular smooth muscle influences key features of blood vessel competency including vascular patterning, ...

Crucial for angiogenesis is the Notch receptor - among others - and its Dll4 ligand. Pitulescu combined genetic experiments with pharmacological approaches. "This approach allowed us to ...