How does Eph-ephrin signaling influence cell organization during development? A great example comes from the neural wiring of the corticospinal tract (CST), which is a pathway that sends messages ...

CSIC researchers have discovered that disturbances to Ephrin B2 and EphB4 signaling pathways—essential for blood vessel formation in the brain—are linked to various vascular malformations.

Stimulation of endothelial cells with ephrin-B2 in the absence of VEGF-C triggers VEGFR-3 internalization but cannot activate signaling, indicating functional cooperation between both pathways.

Why these dramatic mood swings? Blame the Ephrin-A4 receptor, according to a study published February 18 in Proceedings of the National Academy of Sciences. Using inhibitor and conditional knockout ...

This initiates a whole metabolic pathway with different steps that eventually ... The results also reveal how protein levels of ephrin receptor tyrosine kinase B4 (EphB4)—a factor that binds ...