These findings raise the question of whether retroviral VEGF gene therapy is useful for therapeutic ‘angiogenesis’ without risking ‘angioma-genesis’. Overexpression of VEGF may lead to an ...

In tumors, Dll4/Notch signaling appears to dampen (much like a resistor in an electrical circuit) VEGF-stimulated angiogenesis such that a suboptimal, yet sufficiently functional, vascular network ...

Today, angiogenesis is the central focus in the pathogenesis of this disease, with VEGF identified as a major mediator of this process. These advances have opened the door for targeted anti-VEGF ...