The extracellular matrix protein fibronectin forms fibrils when in association with cells that exert tension. Cells apply enough force to stretch fibrils in vivo. Stretching of individual ...

The extracellular matrix (ECM) functions as both a structural scaffold and a regulator of cell signal transduction within tissues. Fibronectin plays a crucial role in the trabecular meshwork (TM ...

ECM contains proteins including collagen, elastin and fibronectin and can be thought of as a sort of "glue" at the organism level that connects the different organs of our body while respecting ...

A discovery by Mayo Clinic researchers may help explain why immunotherapy hasn't been helpful for many patients with metastatic colorectal cancer. In findings published in Clinical Cancer Research, ...

Tumor-initiating cells (blue) produce an extracellular matrix containing fibronectin (pink) which gives them increased stress tolerance, drug resistance and tumor-initiating properties. Disclaimer ...

The FDA has granted fast track designation to Pyxis oncology’s PYX-201 for the treatment of adults with R/M HNSCC.

Endothelial cells are also likely to participate in activation, both by production of cellular fibronectin and via ... emerging as important stimuli to ECM production; their effects may be ...

This study aims to characterise ECM components of the stem cell niche in equine tendon ... by low-density plating and differential adhesion to plastic and fibronectin substrates. Cells were analysed ...