Slow transport via folate receptor (lower affinity for methotrexate than for folic acid) Increased drug efflux via ATP-binding cassette (ABC) subfamily transporters ABCC1–ABCC5 and ABCG2 ...

carbamazepine), methotrexate, sulfasalazine, and specific antibiotics (e.g., trimethoprim), may decrease folate absorption or utilization, potentially leading to an increased risk of a folate ...

Methotrexate 1g/vial ... Infection. Dehydration. Folate deficiency. Ascites, pleural effusions: evacuate fluid, monitor for toxicity and reduce dose or discontinue if needed.

Polymenis said he and his team weren't surprised to see the folate-limited group age healthier. The research team began this work a few years ago by using methotrexate to reduce folate intake in ...

Practice in relation to administration of methotrexate varies considerably ... As substantial genetic variation exists in the folate pathway, 3 dose changes are unlikely to have consistent effects ...

Not surprisingly, therapeutic advancements in children with rheumatic disease have been historically slow, secondary to many factors including the elusive etiology and pathophysiology of these ...

In February 2004, pemetrexed disodium (Alimta; Eli Lilly), an anticancer drug that targets folate-dependent reactions ... The utility of methotrexate has led to considerable efforts to develop ...

Methotrexate 25mg/mL ... Infection. Dehydration. Folate deficiency. Ascites, pleural effusions: evacuate fluid, monitor for toxicity and reduce dose or discontinue if needed.