Researchers have revealed the structure and function of a previously unknown lysosome transporter. The groups of Christian Löw (CSSB, EMBL Hamburg), Markus Damme (Christian-Albrechts-University ...

The discovery of lysosomes led to many new questions. The most critical question was: what was the physiological function of this "bag" of enzymes? The Function of Lysosomes One of the definitive ...

New research has found that lipid peroxidation of lysosomes plays a critical role in the execution of ferroptosis.

Lysosomes are membrane-bound organelles in cells that act as recycling centers—breaking down waste materials, damaged organelles, and unwanted molecules using powerful digestive enzymes.

The Golgi apparatus functions as a molecular assembly line ... they are directed to their appropriate destinations — either lysosomes, storage vesicles, or the plasma membrane (Figure 2).

Scientists have been searching for treatments for neurodegenerative disorders like& Alzheimer's and Parkinson's for many years... | Genetics And Genomics ...

Because lysosome dysfunction is also a prominent ... STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders ...

It has a range of preclinical-stage projects that aim to harness lysosomes’ ability to clear ... Decreased TMEM175 function reduces lysosomal efficiency in neuronal cells, and is strongly ...

The researchers measured nearly 40 percent less LAMP2, LIMP-2, GCase, and cathepsin B in the knockout cell lysosomes. These cells also cleaved prosaposin and progranulin less effectively. Progranulin ...

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death.

Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, ...