The signal transduction cascade begins when adenylyl cyclase, a membrane- bound enzyme, becomes activated by G-protein molecules associated with the adrenergic receptor. Adenylyl cyclase creates ...

and OSI Pharmaceuticals is focusing its preclinical and early clinical efforts on G-protein coupled receptors. In addition, several observations in signal transduction research are showing clear ...

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology ...

Characterizing these signaling complexes has been a major goal for researchers studying signal transduction. But many of these signaling proteins are simply present in quantities too small to be ...

Now, a new study in Science Advances introduces a novel approach to mapping the interactions between 215 such receptors and ...

Attisano, J.L. Wrana, "MADR1, a MAD-related protein that functions in BMP2 signaling pathways ... If there is one thing that is known about the mechanisms that govern signal transduction, it's that ...