Figure 4: Flag–JHDM1A-mediated histone demethylation generates formaldehyde ... The HMTs used include GST–SET7, GST–G9a, CBP–Set2–Flag, GST–hDOT1L, GST–PRMT1, GST–Suv4-20h1 and ...

Histone H3K27 methylation status is regulated by the addition of methyl (Me) groups by the enzyme EZH2 and demethylation by UTX and JMJD3 histone demethylases (Panel A). Lochmann et al.

The new work builds on previous observations from Dr. Elrod's laboratory, particularly their prior discovery of a signaling pathway that promotes myofibroblast formation via histone demethylation.