So-called GABA A receptors are proteins that control the flow of ions into and out of cells. As they play such a vital role in how neurons slow down or stop firing, they have become the targets of ...

“We were unable to identify that individuals with autism had differences in GABAA receptor binding,” says Declan Murphy, a psychiatrist who studies brain development and neuropsychiatric disorders at ...

The determined protein structure of the GABAA receptor, which controls the activity of nerve cells in the brain and spinal cord, showed how well the new method worked. "ONE microscopy makes it ...

which got FDA approval last year for GABAA receptor PAM Zurzuvae (zuranolone) as a treatment for post-partum depression. Another rival is Karuna Therapeutics, acquired by Bristol-Myers Squibb for ...

Two of the most studied forms of plasticity, long-term potentiation (LTP) and long-term depression (LTD), involve both glutamate and GABA (γ-aminobutyric acid) receptors, and it is becoming clear ...

As results indicated that the spinal antinociceptive effect of diazepam is mediated predominately by GABA A receptor isoforms containing the α2 and α3 subunits, the authors next tested whether ...

The phase 2a trial showed rapid onset as well as long-lasting pain reduction with Algiax's allosteric GABAA-receptor modulator AP-325, setting up further trials of the drug. Neuropathic pain can ...

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