in addition to influencing agonist affinity and agonist-mediated endocytosis. Several lines of evidence suggest the existence of GPCR heterodimers. An early study with chimeric receptors between ...

which bind these phosphorylated GPCRs and target them for clathrin-mediated endocytosis. Clearly, the conformational state of a receptor that optimally recognizes a heterotrimeric G protein is not ...