Mok and colleagues hypothesized that first-line therapy with the EGFR inhibitor gefitinib would be at least as efficacious as carboplatin–paclitaxel chemotherapy in former smokers and light ...

Tyrosine kinase inhibitors, such as gefitinib (Iressa ™, ZD1839), block the EGFR. As a result, there is inhibition of cellular proliferation, promotion of apoptosis, and inhibition of anti ...

One of the first EGFR inhibitors in the clinic is gefitinib (Iressa®), a small-molecule tyrosine-kinase inhibitor (TKI). Following four phase I studies, two large phase II trials (IDEAL I and II ...

Sixty lung adenocarcinomas that were known to be sensitive or refractory to single-agent gefitinib or erlotinib were analyzed. Each tumor specimen was screened for mutations in EGFR exons 18–21 ...