Activator proteins bind to regulatory sites on DNA nearby to promoter regions that act as on/off switches. This binding facilitates RNA polymerase activity and transcription of nearby genes.

Being able to predict which genes are turned on, off, up or down in different cells could help determine the cell of origin for a disease. A model that makes accurate predictions about gene ...

Researchers have developed a comprehensive atlas that maps DNA methylation—a critical chemical modification governing gene activity—across 39 human cell types, revealing a complex landscape of ...