Gastrointestinal stromal tumors (GIST) are rare mesenchymal tumors and were among the first solid tumor types for which such a novel treatment (in this case imatinib) became available. The ...

Germ cells and sex cord stromal cells form when a fetus (baby) is developing. A fetus is made from a sperm cell and an egg cell. Germ cell tumors (GCTs) are also known as germ cell cancer. Germ cells ...

Gastrointestinal stromal tumors (GISTs) usually develop as a result of mutations in the gene that encodes stem cell factor receptor tyrosine kinase (KIT). Imatinib, a selective inhibitor of KIT ...