the results of immunostaining being differentially associated with hematopoietic cell lineages provided some clues about potential mechanisms underlying the strict association of CALR mutations ...

To screen for insertion and deletion mutations in CALR exon 9, we designed PCR primers spanning exon 9 and labeled the forward primer with 6-carboxyfluorescein. After PCR, the products were sized ...

Clearance of driver mutations at day 30 after transplantation was associated with a reduced risk of relapse and better survival among patients with myelofibrosis, a German study showed. The ...

In 2013, in the laboratory of Robert Kralovics, researchers discovered that carcinogenic mutations of the gene calreticulin (CALR) were frequently found in affected patients; these are now used ...

INCA033989 targets CALR mutations, showing efficacy in engineered cell lines and mouse models of MPNs, without affecting other cells. CALR mutations are significant in JAK2V617F-negative essential ...

The CALR mutation data plays a critical role in disease prognosis and therapeutic decision-making. This differentiation aligns with the latest National Comprehensive Cancer Network (NCCN ...

In the laboratory of Robert Kralovics it was discovered as early as 2013 that carcinogenic mutations of the gene calreticulin (CALR) were frequently found in affected patients and are now used ...

Based on data contained in the referenced papers and on its own retrospective validation data, NeoGenomics believes the presence of CALR mutation is pathogenic and pathognomonic for myelofibrosis ...

“Just as a 10-year-old would, we can always continue to ask why. Why are there fewer high-risk splicing mutations in CALR-mutant MF and sMF patients? Is there something biologically different in ...