Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress. Proceedings of the National Academy of Sciences , 2015; DOI ...

10, 11 These findings suggest that mitochondrial dynamic changes may serve as sensors of energy stress and initiators ... in hepatocellular carcinoma (HCC), colorectal cancer (CRC) and breast ...

Mitochondrial dysfunction in HCC involves excessive production of reactive oxygen species (ROS) and defects in mitochondrial enzymes. These dysfunctions can lead to altered cellular metabolism and ...

They have now discovered how the mitochondrion calls for help from the cell when it is under stress. Triggers for such stress can be infections, inflammatory diseases or genetic disorders ...

Researchers have investigated to what extent their metabolism has blended with that of their host cells in the course of evolution, using the example of a mitochondrial stress response.

Mitochondrial GRIM19 was progressively downregulated in chronic liver disease tissues, including hepatitis, cirrhosis, and HCC tissues ... (ROS)-mediated oxidative stress, resulting in aberrant ...

Those results suggested that mitochondria might be involved in stress-related symptoms in the animals. But that idea ran contrary to the “synapto-centric” vision of the brain held by many ...